Musetti had a breakthrough season in 2025, reaching his first French Open semifinal and first Australian Open quarterfinal in singles. He also reached the final of the Monte-Carlo Masters, as well as the semifinals of the Madrid Open and the Italian Open, making him the only player to reach the last four or further of all three clay Masters 1000 events this season. These solid results propelled him into the world’s top ten for the first time.
In 2024, Musetti reached the final at Queen's, Umag, and Chengdu, and the semi-finals at Stuttgart and Vienna. He also attained his best Grand Slam result by reaching the semi-finals at Wimbledon. At the Paris Olympics, he beat defending champion Zverev en route to capturing the bronze medal in men's singles.
Musetti is playing the Bank of China Hong Kong Tennis Open for the third consecutive year.